Tuesday, October 7, 2008

Low Antioxidant Level May Damage Fetal Neurons

According to a recent study, fetal neurons that have low levels of a vital antioxidant, glutathione, are the first to die when exposed to alcohol in cell culture and possibly in the living brain.

Normal growth of the fetal brain in animals as well as humans requires that approximately half of the newly formed neurons die by a process called apoptosis. However, when fetal brains are exposed to alcohol, this neuron death is increased. There is evidence that this may be caused by oxidative stress similar to what may also occur in neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases.

When alcohol is involved, 3 percent to 5 percent more neurons die. “Typically when the fetal rat brain is exposed to alcohol, we have observed a 3 percent to 5 percent increase in neuron death that depends on the amount of alcohol and length of exposure,” Dr. Shivani Maffi said.

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